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Moreover, several US Food and Drug Administration-approved clinical medications, including sorafenib and artesunate, demonstrated the ability to induce ferroptosis in numerous types of cancer cells, such as renal cell carcinoma, head and neck cancer and TNBC, which indicates that ferroptosis may be used in both preclinical and clinical settings (111,112)

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studied the mechanisms of increased in vivo brain delivery of the model drug ribavirin when encapsulated into PEGylated liposomes conjugated with GSH, intravenously administered to rats [142]